Thursday, October 25, 2007

Making Science More Better for You on 10/25/07

Headline of the day
Alarming Rise In Naked Hotel Sleepwalkers...
(Matt Drudge)

The other headline of the day
Couple struck and killed after getting out of car to argue (The Obscure Store)
See, it's nice to be nice


So does this make it hot to be cold?

MSNBC reports that Phoenix news site azcentral.com reveals that hotel heiress Paris Hilton is looking forward to an afterlife of suspended animation at the Cryonics Institute, accompanied Egyptian-style with her darling doggies, including Chihuahua Tinkerbell and Yorkie Cinderella.

"It's so cool,” Paris enthused. According to azcentral.com, the blonde celebutante invested thousands in her frigid future. “Almost all the cells in the body are still alive when death is pronounced. And if you're immediately cooled, you can be perfectly preserved.” Just think of it, kids! "My life could be extended by hundreds and thousands of years."

Admit it, the story conjures of the vision of Ms. Hilton, in a frozen galaxy far away, doing the dance of Salome with the head of that other fan of freezing, baseball immortal Ted Williams, on a silver platter. No? Well, it does for us.


We always knew politics was too much monkey business
Humans And Monkeys Share Machiavellian Intelligence

ScienceDaily (Oct. 25, 2007) — When it comes to their social behavior, people sometimes act like monkeys, or more specifically, like rhesus macaques, a type of monkey that shares with humans strong tendencies for nepotism and political maneuvering, according to research by Dario Maestripieri, an expert on primate behavior and an Associate Professor in Comparative Human Development and Evolutionary Biology at the University of Chicago.
"After humans, rhesus macaques are one of the most successful primate species on our planet; our Machiavellian intelligence may be one of the reasons for our success" wrote Maestripieri.*

Maestripieri has been studying monkeys for more than 20 years and has written extensively on their behavior. He has studied them in Europe, at a research center in Atlanta, and on an island in Puerto Rico, where researchers established a rhesus macaque colony for scientific and breeding purposes.

Rhesus macaques live in complex societies with strong dominance hierarchies and long-lasting social bonds between female relatives. Individuals constantly compete for high social status and the power that comes with it using ruthless aggression, nepotism, and complex political alliances. Sex, too, can be used for political purposes. The tactics used by monkeys to increase or maintain their power are not much different from those Machiavelli suggested political leaders use during the Renaissance.

Alpha males, who rule the 50 or so macaques in the troop, use threats and violence to hold on to the safest sleeping places, the best food, and access to the females in the group with whom they want to have sex. Like human dictators intent on holding power, dominant monkeys use frequent and unpredictable aggression as an effective form of intimidation. Less powerful members of the rhesus macaque group are marginalized and forced to live on the edges of the group's area, where they are vulnerable to predator attacks. They must wait for the others to eat first and then have the leftovers; they have sex only when the dominant monkeys are not looking.

"In rhesus society, dominants always travel in business class and subordinates in economy, and if the flight is overbooked, it's the subordinates who get bumped off the plane," Maestripieri said. "Social status can make the difference between life and death in human societies too," he pointed out. In the wake of Hurricane Katrina, for instance, the poorer members of the community accounted for most of the hurricane's death toll.

Male macaques form alliances with more powerful individuals, and take part in scapegoating on the lower end of the hierarchy, a Machiavellian strategy that a mid-ranking monkey can use when under attack from a higher-ranking one. Altruism is rare and, in most cases, only a form of nepotistic behavior. Mothers help their daughters achieve a status similar to their own and to maintain it throughout their lives. Females act in Machiavellian ways also when it comes to reproduction. They make sure they have lots of sex with the alpha male to increase the chances he will protect their newborn infant from other monkeys 6 months later.

"But while they have lots of sex with the alpha male and make him think he's going to be the father of their baby, the females also have sex with all the other males in the group behind the alpha male's back," Maestripieri said. They do so just in case the alpha male is sterile or he dies or loses his power before the baby is born.

Struggles for power within a group sometimes culminate in a revolution, in which all members of the most dominant family are suddenly attacked by entire families of subordinates. These revolutions result in drastic changes in the structure of power within rhesus societies, not unlike those occurring following human revolutions. There is one situation, however, in which all of the well-established social structure evaporates: when a group of rhesus macaques confronts another one and monkey warfare begins. Rhesus macaques dislike strangers and will viciously attack their own image in a mirror, thinking it's a stranger threatening them. When warfare begins, "Even a low-ranking rhesus loner becomes an instant patriot. Every drop of xenophobia in rhesus blood is transformed into fuel for battle," Maestripieri wrote.

"What rhesus macaques and humans may have in common is that many of their psychological and behavioral dispositions have been shaped by intense competition between individuals and groups during the evolutionary history of these species" Maestripieri said. Rhesus groups can function like armies, and this may explain why these monkeys have been so successful in the competition with other primates.

Pressure to find Machiavellian solutions to social problems may also have led to the evolution of larger human brains.

"Our Machiavellian intelligence is not something we can be proud of, but it may be the secret of our success. If it contributed to the evolution of our large brains and complex cognitive skills, it also contributed to the evolution of our ability to engage in noble spiritual and intellectual activities, including our love and compassion for other people", Maestripieri said.

“Someday, and that day may never come, I’ll call upon you to do a service for me. But until that day , accept this banana as a gift on my daughter’s wedding day. Eeeek."

I was kind of sad, now I’m just freakin’ hungry

Cannabis: Potent Anti-depressant In Low Doses, Worsens Depression At High Doses

ScienceDaily (Oct. 24, 2007) — A new neurobiological study has found that a synthetic form of THC, the active ingredient in cannabis, is an effective anti-depressant at low doses. However, at higher doses, the effect reverses itself and can actually worsen depression and other psychiatric conditions like psychosis.

It has been known for many years that depletion of the neurotransmitter serotonin in the brain leads to depression, so SSRI-class anti-depressants like Prozac and Celexa work by enhancing the available concentration of serotonin in the brain. However, this study offers the first evidence that cannabis can also increase serotonin, at least at lower doses.

Laboratory animals were injected with the synthetic cannabinoid WIN55,212-2 and then tested with the Forced Swim test -- a test to measure "depression" in animals; the researchers observed an antidepressant effect of cannabinoids paralleled by an increased activity in the neurons that produce serotonin. However, increasing the cannabinoid dose beyond a set point completely undid the benefits, said Dr. Gabriella Gobbi of McGill University.

"Low doses had a potent anti-depressant effect, but when we increased the dose, the serotonin in the rats' brains actually dropped below the level of those in the control group. So we actually demonstrated a double effect: At low doses it increases serotonin, but at higher doses the effect is devastating, completely reversed."

The anti-depressant and intoxicating effects of cannabis are due to its chemical similarity to natural substances in the brain known as "endo-cannabinoids," which are released under conditions of high stress or pain, explained Dr. Gobbi. They interact with the brain through structures called cannabinoid CB1 receptors. This study demonstrates for the first time that these receptors have a direct effect on the cells producing serotonin, which is a neurotransmitter that regulates the mood.

Dr. Gobbi and her colleagues were prompted to explore cannabis' potential as an anti-depressant through anecdotal clinical evidence, she said. "As a psychiatrist, I noticed that several of my patients suffering from depression used to smoke cannabis. And in the scientific literature, we had some evidence that people treated with cannabis for multiple sclerosis or AIDS showed a big improvement in mood disorders. But there were no laboratory studies demonstrating the anti-depressant mechanism of action of cannabis."

Because controlling the dosage of natural cannabis is difficult -- particularly when it is smoked in the form of marijuana joints -- there are perils associated with using it directly as an anti-depressant.

"Excessive cannabis use in people with depression poses high risk of psychosis," said Dr. Gobbi. Instead, she and her colleagues are focusing their research on a new class of drugs which enhance the effects of the brain's natural endo-cannabinoids.

"We know that it's entirely possible to produce drugs which will enhance endo-cannabinoids for the treatment of pain, depression and anxiety," she said.

Thank you Dr. Cheech. Dr. Chong, is there anything you wish to add?

No comments: