Headline of the day
Irked neighbor saws off left half of tree (CNN)
It's nice to know someone still gets "irked."
Must press button. Must get food. Must crap in hand and throw it at strangers.
Monkeys control a robot arm with their thoughts
By Benedict Carey (International Herald Tribune)
Two monkeys with tiny sensors in their brains have learned to control a mechanical arm with just their thoughts, using it to reach for and grab food and even to adjust for the size and stickiness of morsels when necessary, scientists reported on Wednesday.
The report, released online by the journal Nature, is the most striking demonstration to date of brain-machine interface technology. Scientists expect that technology will eventually allow people with spinal cord injuries and other paralyzing conditions to gain more control over their lives.
The findings suggest that brain-controlled prosthetics, while not practical, are at least technically within reach.
In previous studies, researchers showed that humans who had been paralyzed for years could learn to control a cursor on a computer screen with their brain waves and that nonhuman primates could use their thoughts to move a mechanical arm, a robotic hand, a robot on a treadmill or a small vehicle.
The new experiment goes a step further. In it, the monkeys' brains seem to have adopted the mechanical appendage as their own, refining its movement as it interacted with real objects in real time. The monkeys had their own arms gently restrained while they learned to use the added one.
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Experts not involved with the study said the findings were likely to accelerate interest in human testing, especially given the need to treat head and spinal injuries in veterans returning from Iraq and Afghanistan.
"This study really pulls together all the pieces from earlier work and provides a clear demonstration of what's possible," said Dr. William Heetderks , director of the extramural science program at the National Institute of Biomedical Imaging and Bioengineering.
Dr. John Donoghue, director of the Institute of Brain Science at Brown University, said the new report was "important because it's the most comprehensive study showing how an animal interacts with complex objects, using only brain activity."
The researchers, from the University of Pittsburgh and Carnegie Mellon University, used monkeys partly because of their anatomical similarities to humans and partly because they are quick learners.
In the experiment, two macaques first used a joystick to gain a feel for the arm, which had shoulder joints, an elbow and a grasping claw with two mechanical fingers.
Then, just beneath the monkeys' skulls, the scientists implanted a grid about the size of a large freckle. It sat on the motor cortex, over a patch of cells known to signal arm and hand movements. The grid held 100 tiny electrodes, each connecting to a single neuron, its wires running out of the brain and to a computer.
The computer was programmed to analyze the collective firing of these 100 motor neurons, translate that sum into an electronic command and send it instantaneously to the arm, which was mounted flush with the left shoulder.
The scientists used the computer to help the monkeys move the arm at first, essentially teaching them with biofeedback.
After several days, the monkeys needed no help. They sat stationary in a chair, repeatedly manipulating the arm with their brain to reach out and grab grapes, marshmallows and other nuggets dangled in front of them. The snacks reached the mouths about two-thirds of the time — an impressive rate, compared with earlier work.
The monkeys learned to hold the grip open on approaching the food, close it just enough to hold the food and gradually loosen the grip when feeding.
On several occasions, a monkey kept its claw open on the way back, with the food stuck to one finger. At other times, a monkey moved the arm to lick the fingers clean or to push a bit of food into its mouth while ignoring a newly presented morsel.
The animals were apparently freelancing, discovering new uses for the arm, showing "displays of embodiment that would never be seen in a virtual environment," the researchers wrote.
"In the real world, things don't work as expected," said the senior author of the paper, Dr. Andrew Schwartz, a professor of neurobiology at the University of Pittsburgh. "The marshmallow sticks to your hand or the food slips, and you can't program a computer to anticipate all of that.
"But the monkeys' brains adjusted. They were licking the marshmallow off the prosthetic gripper, pushing food into their mouth, as if it were their own hand."
The co-authors were Meel Velliste, Sagi Perel, M. Chance Spalding and Andrew Whitford.
Scientists have to clear several hurdles before this technology becomes practical, experts said. Implantable electrode grids do not generally last more than a period of months, for reasons that remain unclear.
The equipment to read and transmit the signal can be cumbersome and in need of continual monitoring and recalibrating. And no one has yet demonstrated a workable wireless system that would eliminate the need for connections through the scalp.
Yet Schwartz's team, Donoghue's group and others are working on all of the problems, and the two macaques' rapid learning curve in taking ownership of a foreign limb gives scientists confidence that the main obstacles are technical and, thus, negotiable.
In an editorial accompanying the Nature study, Dr. John Kalaska, a neuroscientist at the University of Montreal, argued that after such bugs had been worked out, scientists might even discover areas of the cortex that allow more intimate, subtle control of prosthetic devices.
Such systems, Kalaska wrote, "would allow patients with severe motor deficits to interact and communicate with the world not only by the moment-to-moment control of the motion of robotic devices, but also in a more natural and intuitive manner that reflects their overall goals, needs and preferences."
They knew it was Viking DNA because it wore a tiny hat with little horns on it and kept asking for lutefisk.
Authentic Viking DNA Retrieved From 1,000-year-old Skeletons
ScienceDaily (May 28, 2008) — Although "Viking" literally means "pirate," recent research has indicated that the Vikings were also traders to the fishmongers of Europe. Stereotypically, these Norsemen are usually pictured wearing a horned helmet but in a new study, Jørgen Dissing and colleagues from the University of Copenhagen, investigated what went under the helmet; the scientists were able to extract authentic DNA from ancient Viking skeletons, avoiding many of the problems of contamination faced by past researchers.
Analysis of DNA from the remains of ancient humans provides valuable insights into such important questions as the origin of genetic diseases, migration patterns of our forefathers and tribal and family patterns.
Unfortunately, severe problems connected with the retrieval and analysis of DNA from ancient organisms (like the scarcity of intact molecules) are further aggravated in the case of ancient humans. This is because of the great risk of contamination with abundant DNA from modern humans. Humans, then, are involved at all steps, from excavation to laboratory analyses. This means that many previous results have subsequently been disputed as attributed to the presence of contaminant DNA, and some researchers even claim that it is impossible to obtain reliable results with ancient human DNA.
Using freshly sampled material from ten Viking skeletons from around AD 1,000, from a non-Christian burial site on the Danish island of Funen, Dissing and colleagues showed that it is indeed possible to retrieve authentic DNA from ancient humans.
Wearing protective suits, the researchers removed the teeth from the jaw at the moment the skeletons were unearthed when they had been untouched for 1,000 years. The subsequent laboratory procedures were also carefully controlled in order to avoid contamination.
Analysis of the Viking DNA showed no evidence of contamination with extraneous DNA, and typing of the endogenous DNA gave reproducible results and showed that these individuals were just as diverse as contemporary humans. A reliable retrieval of authentic DNA opens the way for a valuable use of prehistoric human remains to illuminate the genetic history of past and extant populations.
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